Acetyl chloride → HCID 18187740, compound

Participants

Reaction Steps

Acetyl chloride (0.3 mL) was added dropwise to a solution of 320 mg of 1-t-butyloxycarbonyl-4-(2-benzyl-thiazol-5-yl)piperidine in methanol (2 mL) at ice bath temperature. The reaction mixture was stirred 3.5 hr as it warmed to room temperature. Solvent removal in vacuo gave the desired amine as glassy solid. 1H NMR (CD3OD): 1.94 (m, 2H), 2.24 (m, 2H), 3.1˜3.5 (m, 5H), 4.58 (s, 2H), 7.4 (m, 5H) 8.02(s, 1H).

Provenance & Evidence