Potassium Hydroxide → HCID 18187815, compound

Participants

Reaction Conditions

Reaction Steps

To 40 mg of 1-benzoyl-4-(2-benzyl-oxazol-5-yl)piperidine (step F) in 4.5 mL MeOH and 0.5 ml H2O was added 260 mg of potassium hydroxide. The reaction was stirred at 80° C. overnight, 20 ml of H2O was added and the mixture was extracted with 3×20 mL EtOAc. The combined organic layer was dried over MgSO4. The solvent was evaporated under reduced pressure to give 22 mg of the title compound. ESI-MS 242.9 (M+H); HPLC A: 2.29 min.

Provenance & Evidence