1-(1-Benzylpiperidin-4-yl)ethanone → 1-(1-Benzylpiperidin-4-yl)-4-(4-t-butoxyphenyl)butane-1,3-dione

Participants

Reaction Steps

The title compound was prepared using a procedure similar to that described in Example 13 Step C from 1-benzyl-4-acetylpiperidine and methyl 4-t-butoxyphenylacetate in 87% yield. 1H NMR (500 MHz) δ 7.30˜7.35 (m, 4H), 7.24˜7.29 (m, 1H), 7.12˜7.15 (m, 2H), 6.95˜6.97 (m, 2H), 3.57 (s, 2H), 3.50 (s, 2H), 2.91˜2.95 (m, 2H), 2.15 (tt, 3.9 & 11.8 Hz, 1H), 1.95˜2.01 (m, 2H), 1.75˜1.80 (m, 2H), 1.63˜1.72 (m, 2H), 1.36 (s, 9H).

Provenance & Evidence