HCID 18187452, compound → HCID 131722704, compound

HRID 1068250Notes

Reaction equation

[C:1]([O:5][C:6]1[CH:25]=[CH:24][C:9]([CH2:10][C:11]2[CH:15]=[C:14]([CH:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[N:13]([CH2:22][CH3:23])[N:12]=2)=[CH:8][CH:7]=1)([CH3:4])([CH3:3])[CH3:2].[CH:26]([C@@H:28]1[C@@H:32]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=2)[CH2:31][N:30]([C@H:40]([CH:51]2[CH2:56][CH2:55][CH2:54][CH2:53][CH2:52]2)[C:41]([O:43]CC2C=CC=CC=2)=[O:42])[CH2:29]1)=O>>[NH4+:12].[C:1]([O:5][C:6]1[CH:25]=[CH:24][C:9]([CH2:10][C:11]2[CH:15]=[C:14]([CH:16]3[CH2:21][CH2:20][N:19]([CH2:26][C@@H:28]4[C@@H:32]([C:33]5[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=5)[CH2:31][N:30]([C@H:40]([CH:51]5[CH2:56][CH2:55][CH2:54][CH2:53][CH2:52]5)[C:41]([O-:43])=[O:42])[CH2:29]4)[CH2:18][CH2:17]3)[N:13]([CH2:22][CH3:23])[N:12]=2)=[CH:8][CH:7]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 18187452HCID 18187452, compound

HCID 59924629HCID 59924629, compound

Product 1

HCID 131722704HCID 131722704, compound

Procedure

The title compound was prepared using procedures described in Example 570 Steps D and E using 4-(3-(4-t-butoxybenzyl)-1-ethyl-(1H-pyrazol-5-yl))piperidine, from Example 570 Step C and Aldehyde 6. ESI-MS 659.4 (M+H), HPLC A: 4.10 min.

Workup

custom4.10 min.

Sources & evidence

ORD record: ord-5007e906b8784a5187f6b11c9e80dbad
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06248755B1

Reaction notes

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