Silane, chloro(chloromethyl)dimethyl- → n,n-Diethyl-2-chloro-6-[(chloromethyl)dimethylsilyl]benzamide

HRID 1068286Notes

Reaction equation

HRID 1068286 reaction equation
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[Cl:15][CH2:16][Si:17](Cl)([CH3:19])[CH3:18]>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([Si:17]([CH2:16][Cl:15])([CH3:19])[CH3:18])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

Participants

3

Reactant 2

HCID 74393Silane, chloro(chloromethyl)dimethyl-HCID 825662-Chloro-N,N-diethylbenzamide

Product 1

HCID 18630016n,n-Diethyl-2-chloro-6-[(chloromethyl)dimethylsilyl]benzamide

Procedure

The title compound was prepared according to General Method A from the compound of Example e and 1.5 eq (chloromethyl)dimethylsilyl chloride. Purification by HPLC using 1:9 ethyl acetate/hexanes gave 5.4 g of the desired compound as a yellow oil, an 85% yield.

Workup

  1. customThe title compound was prepared
  2. customPurification by HPLC

Sources & evidence

ORD record
ord-bbe2222e469f4fe5ad572544ca7a7a61
Source dataset
uspto-grants-2001_06
Patent number
US06248894B1

Reaction notes

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