Methyl iodide → HCID 18630005, compound

HRID 1068311Notes

Reaction equation

HRID 1068311 reaction equation
[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2].[CH3:19]I>>[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[C:6]([Si:11]([CH3:13])([CH3:12])[CH3:14])=[CH:7][CH:8]=[CH:9][C:10]=1[CH3:19])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18630303HCID 18630303, compound

Product 1

HCID 18630005HCID 18630005, compound

Procedure

The compound of Example 50 (1.33 g, 5.0 mmol) and MeI (2.8 g, 20 mmol) were combined according to General Method B. The resulting reaction was partitioned between ethyl acetate and sat aq NaHCO3. The organic phase was washed with brine, dried (MgSo4), and concentrated to afford a quantitative yield of the title compound as an oil.

Workup

  1. customThe resulting reaction
  2. customwas partitioned between ethyl acetate
  3. washThe organic phase was washed with brine
  4. customdried (MgSo4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-ccc8f3b0864b4d9ca37ee9cc2f3f9a52
Source dataset
uspto-grants-2001_06
Patent number
US06248894B1

Reaction notes

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