Ethylamine → HCID 18630302, compound

HRID 1068319Notes

Reaction equation

HRID 1068319 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:3]=1[C:4](Cl)=[O:5].[CH2:15]([NH2:17])[CH3:16]>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:3]=1[C:4]([NH:17][CH2:15][CH3:16])=[O:5]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 18630170HCID 18630170, compound

Product 1

HCID 18630302HCID 18630302, compoundYield 92%

Procedure

The compound of Example d (38.19 g, 0.13 mol) was reacted with 70% aqueous ethylamine (53 mL) according to General Method E1 and recrystallized from methylcyclohexane to afford the title compound as light tan crystals in 92% yield. m.p. 121-122° C.

Workup

  1. customrecrystallized from methylcyclohexane

Sources & evidence

ORD record
ord-607504de97704f0f9f7fb8980f21ed1a
Source dataset
uspto-grants-2001_06
Patent number
US06248894B1

Reaction notes

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