Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(1,1-Dimethylethyl) 4-methyl 4-[(2-methylphenyl)methyl]-1,4-piperidinedicarboxylate | HCID 53775443 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21193404 | HCID 21193404 | — |
Reaction Steps
To a solution of N-t-butoxycarbonyl-4-(2-methylbenzyl)-isonipecotic acid methyl ester (7.13 g, 20.5 mmol) in EtOAc (100 ml) at 0° C. was bubbled HCl gas until saturated. The reaction was stirred for 10 min at 0° C. and the solvent evaporated in vacuo to afford the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06248756B1 |
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| Source dataset | uspto-grants-2001_06 |
|---|
| ORD ID | ord-05cdaa3480f547cbb8ff996a1a90a812 |
|---|
| Source note | uspto-grants-2001_06 |
|---|
