Water → HCID 21193346, compound

Participants

Reaction Steps

A mixture of the alcohol from Step A (218 mg, 0.82 mmol), tetradecyl bromide (170 μL, 0.9 mmol) and CSCO3 (532 mg, 1.63 mmol) in DMF (8 mL) was stirred for 16 hs at room temperature under argon. The mixture was poured into water and extracted with EtOAc. The organic extracts were combined, washed with water and brine, dried (MgSO4), and concentrated in vacuo to give an oil. Purification by chromatography (SiO2, 20% EtOAc in hexanes) gave the title compound as a solid.

Provenance & Evidence