HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-phenylpiperidine-4-carboxylate → 1-Phenylpiperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-phenylpiperidine-4-carboxylate | HCID 6470 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Phenylpiperidine-4-carboxylic acid | HCID 3023990 | — |
Reaction Steps
The product from Step C was dissolved in methanol and 5% aqueous sodium hydroxide added. After 1 h, methanol was removed in vacuo, and the residue partitioned between ethyl acetate and 10% aqueous HCl. The organic layer was washed with saturated brine, and dried over MgSO4. Filtration and concentration provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248756B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-a170670efb9444dda237642fa0449b8a |
| Source note | uspto-grants-2001_06 |