HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1068431Generated: November 1, 2026
Sodium Iodide → diethyl ((1-(triphenylmethyl)-1H-imidazol-4-yl)methyl)phosphonate
https://huagongshe.com/reaction/1068431
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | 4-(Chloromethyl)-1-trityl-1H-imidazole | HCID 2763176 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | diethyl ((1-(triphenylmethyl)-1H-imidazol-4-yl)methyl)phosphonate | HCID 2763175 | — |
Reaction Steps
The product from Step C is dissolved in acetonitrile and cooled to 0° C. Triethyl phosphite (1 equivalent) and sodium iodide (1 equivalent) are added, and the reaction stirred at room temperature overnight. The reaction is quenched with ammonium chloride, and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and concentrated to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06248756B1 |
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| Source dataset | uspto-grants-2001_06 |
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| ORD ID | ord-cac0de4c6d3d4811ba0d045afa69d729 |
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| Source note | uspto-grants-2001_06 |
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