反应详情

A mixture of 1-(4-cyanobenzyl)-5-hydroxymethyl-2-methylimidazole (3.45 g, 15.2 mmol) and thionyl chloride (30 mL, 411 mmol) was stirred at room temp. overnight under a calcium chloride drying tube. The resultant mixture was concentrated under vacuum, and residual thionyl chloride was removed by co-evaporation with toluene. The residue was triturated with anhydrous diethyl ether, filtered, washed with ether to provide the title compound as white solid.

1. concentrationThe resultant mixture was concentrated under vacuum, and residual thionyl chloride
2. customwas removed by co-evaporation with toluene
3. customThe residue was triturated with anhydrous diethyl ether
4. filtrationfiltered
5. washwashed with ether