Lithium Chloride → methyl 1-[3-(4-cyanobenzyl)-3H-imidazol-4-ylcarbonyl]-4-(3-methylbenzyl)piperidine-4-carboxylate
Reaction equation
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[CH2:6][C:7]1([C:13]([O:15][CH3:16])=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.C(C1C=CC(CN2C(CC(O)=O)=CN=C2)=CC=1)#N.[Cl-].[Li+].[C:40]([C:42]1[CH:56]=[CH:55][C:45]([CH2:46][N:47]2[C:51]([C:52](O)=[O:53])=[CH:50][N:49]=[CH:48]2)=[CH:44][CH:43]=1)#[N:41]>>[C:40]([C:42]1[CH:56]=[CH:55][C:45]([CH2:46][N:47]2[C:51]([C:52]([N:10]3[CH2:9][CH2:8][C:7]([CH2:6][C:5]4[CH:17]=[CH:18][CH:19]=[C:3]([CH3:2])[CH:4]=4)([C:13]([O:15][CH3:16])=[O:14])[CH2:12][CH2:11]3)=[O:53])=[CH:50][N:49]=[CH:48]2)=[CH:44][CH:43]=1)#[N:41]Participants
5
Reactant 4
Product 1
Procedure
The title compound was prepared according to the procedure described in Example 38, Step B substituting 4-(3-methylbenzyl)-4-hydroxymethylpiperidine hydrochloride salt with methyl 4-(3-methylbenzyl)piperidine-4-carboxylate hydrochloride salt (Example 61, Step B), and 1-(4-cyanobenzyl)imidazole-5-acetic acid.lithium chloride with 1-(4-cyanobenzyl)imidazole-5-carboxylic acid.
Sources & evidence
- ORD record
- ord-6b7f27fc17b9458888b562f9aed0060f
- Source dataset
- uspto-grants-2001_06
- Patent number
- US06248756B1
Reaction notes
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