HCID 21193266, compound → HCID 178451996, compound

HRID 1068474Notes

Reaction equation

HRID 1068474 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23]CC3C=CC=CC=3)[N:18]=2)([CH2:14][OH:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[N:18]=2)([CH2:14][OH:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 21193266HCID 21193266, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178451996HCID 178451996, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of N-tert-butoxycarbonyl-4-(6-benzyloxypyridin-2-ylmethyl)-4-hydroxymethylpiperidine (0.19 g, 0.5 mmol) and 5% palladium on charcoal (38 mg) in absolute ethanol (10 mL) was stirred under a balloon of hydrogen gas at room temp. for 3 h. The resultant mixture was filtered through a plug of Celite. The filtrate was concentrated under vacuum to provide the title compound as colorless gum.

Workup

  1. filtrationThe resultant mixture was filtered through a plug of Celite
  2. concentrationThe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-0ac8875126284cf391ac6daad106a75d
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

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