反应详情

A mixture of 1-benzyl-4-(3-methylphenylamino)piperidine-4-carboxylic acid (3.81 g, 11.7 mmol) and concentrated sulfuric acid (2 mL) in absolute ethanol (80 mL) was heated under reflux overnight. The resultant solution was concentrated under vacuum, and the residue was treated with chloroform saturated with ammonia gas. The mixture was filtered, and the filtrate concentrated. The residue was passed through a small plug of silica gel eluting with chloroform saturated with ammonia gas. Collection and concentration of the eluent under vacuum provided the title compound.

1. temperaturewas heated
2. temperatureunder reflux overnight
3. concentrationThe resultant solution was concentrated under vacuum
4. additionthe residue was treated with chloroform saturated with ammonia gas
5. filtrationThe mixture was filtered
6. concentrationthe filtrate concentrated
7. customCollection and concentration of the eluent under vacuum