HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2,3-Dihydro-2-trifluoroacetyl-1h-benz[de]isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Trifluoroacetamide | HCID 67717 | — |
| Reactant | 1,8-Bis(bromomethyl)naphthalene | HCID 291208 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,3-Dihydro-2-trifluoroacetyl-1h-benz[de]isoquinoline | HCID 21189590 | — |
Reaction Steps
Trifluoroacetamide (10 mmol) is reacted with 1,8-bis(bromomethyl)naphthalene (10 mmol) and sodium hydride (10 mmol) in DMF according to the procedure of Wright et al (Biochim. Biophys. Acta 1990, 1040, 95-101) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251890B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-83b03a2002d44af7ae0504b759e013df |
| Source note | uspto-grants-2001_06 |