7-Chloro-6-fluoro-1,4-dihydro-5-nitro-2,3-quinoxalinedione → HCID 10849759, compound

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Reaction Steps

To a stirred solution of 7-Chloro-6-fluoro-5-nitroquinoxaline-2(1H),3(4H)dione (0.100 g, 0.385 mmol, as prepared above) in DMSO (1.0 mL) at room temperature, sodium methoxide (0.125 g, 2.31 mmol, Mallinckrodt) was added in one port. The resulting dark red solution was stirred overnight at room temperate. It was then diluted with water (5.0 mL) and acidified with concentrated HCl (6 drops) to pH ˜2. The precipitated solid was filtered, washed with water (5.0 mL), and dried under vacuum to obtain 0.116 g (110%) of pure (1H NMR) title compound as a yellow powder; m. p. darkens at 316° C.; 1H NMR (DMSO-d6): δ 3.821 (s, 3H), 7.275 (s, 1H), 12.079 (s, 1H) 12.121 (s, 1H). The NMR also indicates the presence of DMSO (reaction solvent).

Provenance & Evidence