Potassium Nitrate → 1-Chloro-2,5-difluoro-4-nitrobenzene

HRID 1068647Notes

Reaction equation

HRID 1068647 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[F:9].[N+:10]([O-])([O-:12])=[O:11].[K+]>OS(O)(=O)=O>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][C:3]=1[F:9]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 1375611-Chloro-2,5-difluorobenzene

Product 1

HCID 157514831-Chloro-2,5-difluoro-4-nitrobenzeneYield 85%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a stirred solution of 1-chloro-2,5-difluorobenzene (0.770 g, 5.18 mmol) in concd H2SO4 (8.0 mL) at 0° C., KNO3.(0.525 g, 5.19 mmol) was added in one lot. The resulting yellow solution was allowed to warm to room temperature and stirred overnight at room temperature. It was then poured into ice (80 g) and extracted with ethyl acetate (75 mL). The ethyl acetate was dried over anhydrous Na2SO4, removed under vacuum and the residue was dried further under vacuum to afford 0.845 g (85%) of title compound as a yellow liquid; 1H NMR (CDCl3) δ 7.43 (dd, 1H, J1=9.6 Hz, J2=6.0 Hz), 7.93 (t, 1H, J=7.2 Hz).

Workup

  1. customat 0° C.
  2. addition(0.525 g, 5.19 mmol) was added in one lot
  3. extractionextracted with ethyl acetate (75 mL)
  4. dry with materialThe ethyl acetate was dried over anhydrous Na2SO4
  5. customremoved under vacuum
  6. customthe residue was dried further under vacuum

Sources & evidence

ORD record
ord-5c195ed4940a49aab094b7143c470784
Source dataset
uspto-grants-2001_06
Patent number
US06251903B1

Reaction notes

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