HCID 15859296, compound → HCID 15859292, compound

HRID 1068689Notes

Reaction equation

HRID 1068689 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]([O:21][CH3:22])=[O:20])[CH:17]=2)[NH:12][CH:11]=1)(=O)=O.[O:23]=[C:24]1[CH:29]=[CH:28][C:27]2[CH:30]=[C:31]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)[CH:32]=[CH:33][C:26]=2[O:25]1>C(#N)C>[O:23]=[C:24]1[CH:29]=[CH:28][C:27]2[CH:30]=[C:31]([N:34]3[CH2:35][CH2:36][N:37]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]4[C:18]5[C:13](=[CH:14][CH:15]=[C:16]([C:19]([O:21][CH3:22])=[O:20])[CH:17]=5)[NH:12][CH:11]=4)[CH2:38][CH2:39]3)[CH:32]=[CH:33][C:26]=2[O:25]1

Participants

4

Reactant 2

HCID 15859296HCID 15859296, compoundHCID 15859297HCID 15859297, compound

Product 1

HCID 15859292HCID 15859292, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 0.0098 mol of 4-(5-methoxycarbonylindol-3-yl)butyl methanesulfonate (preparation as described in Example 3) and 0.0097 mol of 4-(2-oxo-2H-1-benzopyran-6-yl)piperazine is heated in acetonitrile for about 96 hours on a steam bath. The reaction mixture is worked up in the customary manner and purified. Methyl 3-{4-[4-(2-oxo-2H-1-benzopyran-6-yl)-1-piperazinyl]-butyl}indole-5-carboxylate is thus obtained.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-33a48be1f3604b33b7066f15b324eb2d
Source dataset
uspto-grants-2001_06
Patent number
US06251908B1

Reaction notes

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