HCID 15859292, compound → HCID 15859293, compound

HRID 1068690Notes

Reaction equation

HRID 1068690 reaction equation
[O:1]=[C:2]1[CH:7]=[CH:6][C:5]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]4[C:30]5[C:25](=[CH:26][CH:27]=[C:28]([C:31]([O:33]C)=[O:32])[CH:29]=5)[NH:24][CH:23]=4)[CH2:14][CH2:13]3)[CH:10]=[CH:11][C:4]=2[O:3]1>[OH-].[K+]>[O:1]=[C:2]1[CH:7]=[CH:6][C:5]2[CH:8]=[C:9]([N:12]3[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]4[C:30]5[C:25](=[CH:26][CH:27]=[C:28]([C:31]([OH:33])=[O:32])[CH:29]=5)[NH:24][CH:23]=4)[CH2:16][CH2:17]3)[CH:10]=[CH:11][C:4]=2[O:3]1

Participants

3

Reactant 1

HCID 15859292HCID 15859292, compound

Product 1

HCID 15859293HCID 15859293, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

1.8 g of methyl 3-{4-[4-(2-oxo-2H-1-benzopyran-6-yl)-1-piperazinyl]butyl}indole-5-carboxylate are boiled for 30 minutes with 100 ml of 2N ethanolic KOH and worked up in the customary manner and 3-{4-[4-(2-oxo-2H-1-benzopyran-6-yl)-1-piperazinyl]butyl}indole-5-carboxylic acid is obtained.

Sources & evidence

ORD record
ord-40f91202479c4ec9b3355a9afd474283
Source dataset
uspto-grants-2001_06
Patent number
US06251908B1

Reaction notes

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