反应详情

To a suspension of 2.94 g (7.31 mmol) of 1,2-dihydro-3-methyl-1-[6-(phthalimido)hexan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 80 ml of ethanol was added 1.10 g (22.0 mmol) of hydrazine.monohydrate. The mixture was heated for 2 hours under reflux. After cooling, the resulting precipitates were filtered off. The filtrate was concentrated to give the residue, water was added, extracted with chloroform (three times). The extract was dried over anhydrous magnesium sulfate, then the solvent was distilled off to give 1.50 g of the desired compound (75.4%, pale yellow solid).

1. temperatureThe mixture was heated for 2 hours
2. temperatureunder reflux
3. temperatureAfter cooling
4. customthe resulting precipitates
5. filtrationwere filtered off
6. concentrationThe filtrate was concentrated
7. customto give the residue, water
8. additionwas added
9. extractionextracted with chloroform (three times)
10. dry with materialThe extract was dried over anhydrous magnesium sulfate
11. distillationthe solvent was distilled off