反应详情

To a suspension of 2.50 g (6.2 mmol) of 3-methyl-2-[5-(phthalimido)pentan-1-ylthio]-1,4,7b-triazacyclopent[cd]indene in 50 ml of ethanol was added 928 mg (18.5 mmol) of hydrazinemonohydrate. The mixture was heated for two hours under reflux. After cooling, the resulting precipitates were collected by filtration and washed with ethanol. The filtrate and washing were combined and concentrated to give the residue. Water was added, extracted with methylene chloride, dried over anhydrous magnesium sulfate. The solvent was distilled off to afford 1.197 g of the desired compound (70.6%, a greenish brown solid).

1. additionwas added 928 mg (18.5 mmol) of hydrazinemonohydrate
2. temperatureThe mixture was heated for two hours
3. temperatureunder reflux
4. temperatureAfter cooling
5. customthe resulting precipitates
6. filtrationwere collected by filtration
7. washwashed with ethanol
8. washThe filtrate and washing
9. concentrationconcentrated
10. customto give the residue
11. extractionextracted with methylene chloride
12. dry with materialdried over anhydrous magnesium sulfate
13. distillationThe solvent was distilled off