Ammonia → 3H-1,4,8b-Triazaacenaphthylene-3,5(4H)-dione

HRID 1068816Notes

Reaction equation

HRID 1068816 reaction equation
C(O[C:4]([C:6]1[N:11]2[C:12]([C:15](=[O:20])C(Cl)(Cl)Cl)=[CH:13][N:14]=[C:10]2[CH:9]=[CH:8][CH:7]=1)=[O:5])C.[NH3:21]>C(#N)C>[N:14]1[CH:13]=[C:12]2[N:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=13)[C:4](=[O:5])[NH:21][C:15]2=[O:20]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 15472383HCID 15472383, compound

Product 1

HCID 211901623H-1,4,8b-Triazaacenaphthylene-3,5(4H)-dioneYield 27.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 2.64 g (7.55 mmol) of 5-ethoxycarbonyl-3-trichloroacetylimidazo[1,2-a]pyridine in 20 ml of acetonitrile was added 2.5 ml of 25% aqueous ammonia. The mixture was stirred for 5 hours at room temperature. The resulting crystals were collected by filtration and washed with acetonitrile to give 393 mg of the desired compound (27.8%, pale brown solid).

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with acetonitrile

Sources & evidence

ORD record
ord-8688d571dde44e68a4f5ce1a8921af5d
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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