HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Bromomethyl)-1-methylquinolin-2(1H)-one → 1,2,3,4-Tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Bromomethyl)-1-methylquinolin-2(1H)-one | HCID 15199065 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Product | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
Reaction Steps
The alkylation step was carried out using 6-bromomethyl-1-methyl-2-oxo-1,2-dihydroquinoline, as in Example 1, and the intermediate was reduced with hydrogen over an Adam's catalyst to give 1,2,3,4-tetrahydroquinoline intermediate which was then deprotected as in Example 13. This provided the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251913B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-c42f90e8facf4c51a49e397944392be0 |
| Source note | uspto-grants-2001_06 |