Dimethylformamide → HCID 21190779, compound

Participants

Reaction Steps

The product of the preceding example, DMF (10 mL), the product of example 1 (b) (1.59 g, 5.5 mmol) and KCO3 (0.308 g, 2.23 mmol) were combined and stirred for 2 days, diluted with Et2O and filtered. The filtrate was concentrated under high vacuum to a brown paste. Trituration with Et2O and hexane (1:1, 200 mL) afforded the title compound as a tan solid. Crystallization from EtOAc/hexane (1:4) afforded 0.631 g (39% from the product of example 1(d). ESP+ (Mass Spec) m/z 353 (MH+). mp=207-208.

Provenance & Evidence