2-Naphthalenesulfonyl chloride → HCID 20666635, compound

HRID 1068850Notes

Reaction equation

HRID 1068850 reaction equation
[NH2:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]([NH:6][C@@H:7]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:8][OH:9])=[O:5].[CH:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1[S:31](Cl)(=[O:33])=[O:32]>>[CH:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1[S:31]([NH:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]([NH:6][C@@H:7]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][OH:9])=[O:5])(=[O:32])=[O:33]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 206666372-Amino-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]benzamide2×

Product 1

HCID 20666635HCID 20666635, compound

Procedure

1.5 g (5.6 mmol) of (S)-2-amino-N-(3-phenylpropan-1-ol-2-yl)benzamide (intermediate 4a) were reacted with 2-naphthylsulfonyl chloride by the method of procedure 4b. 0.67 g of the product was obtained.

Sources & evidence

ORD record
ord-2fb93bb8b3c248a5b0cc337117c7918a
Source dataset
uspto-grants-2001_06
Patent number
US06251917B1

Reaction notes

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