Methyl Salicylate → HCID 21190790, compound

Participants

Reaction Conditions

Reaction Steps

3.9 g (35 mmol) of potassium tert-butoxide were added a little at a time to 5 g (33 mmol) of methyl hydroxybenzoate in 200 ml of dimethylformamide. After about 15 min, a further 7.3 g (33 mmol) of 2-(bromomethyl)naphthalene were added and the reaction mixture was heated to 100° C. for about 3 h. The reaction mixture was then poured into ice-water and the product was extracted with ethyl acetate. The organic phase was dried and concentrated under reduced pressure. 8.4 g (88%) of the product were obtained.

Provenance & Evidence