2-Phenoxybenzoic acid → HCID 20666651, compound

HRID 1068858Notes

Reaction equation

[NH2:1][C@@H:2]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][OH:4].[O:12]([C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[O:12]([C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([NH:1][C@@H:2]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][OH:4])=[O:22])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 752372-Phenoxybenzoic acid

HCID 447213phenylalaninol, (S)-

Product 1

HCID 20666651HCID 20666651, compoundYield 103.7%

Procedure

7.3 g (48 mmol) of (S)-2-amino-3-phenyl-1-propanol were reacted with 10.7 g (50 mmol) of 2-phenoxybenzoic acid by the method of procedure 3c. 17.3 g (100%) of the product were obtained.

Sources & evidence

ORD record: ord-cbd15ec3474f456db7b89779210bce5d
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06251917B1

Reaction notes

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