HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide diethylacetal → N'-(3-benzylamino-4-cyano-1H-pyrazol-5-yl)-N,N-dimethylformamidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide diethylacetal | HCID 70913 | — |
| Reactant | 5-amino-3-benzylamino-1H-pyrazole-4-carbonitrile | HCID 10822472 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N'-(3-benzylamino-4-cyano-1H-pyrazol-5-yl)-N,N-dimethylformamidine | HCID 53832654 | — |
Reaction Steps
Under a nitrogen atmosphere, a suspension of 74.3 g (348 mmol) of 5-amino-3-benzylamino-1H-pyrazole-4-carbonitrile in 1.0 liter of toluene is boiled under reflux for 2 hours with 70.1 ml (95%; 409 mmol) of N,N-dimethylformamide diethyl acetal. Cooling to RT, filtration with suction and washing with diethyl ether yield N′-(3-benzylamino-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyl-formamidine; m.p. 197-200° C.; TLC: Rf=0.50 (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251911B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-b54cad5f2008443680dd410ed500e0f3 |
| Source note | uspto-grants-2001_06 |