4-Methylmorpholine → HCID 178453816, compound

Participants

Reaction Steps

Analogously to Example 5. 502 mg (2.86 mmol) of N-isobutyloxycarbonyl-glycine in 5.9 ml of THF and 580 μl (5.3 mmol) of NMM are activated with 375 μl (2.86 mmol) of isobutyl chloroformate and then reacted with 745 mg (2.86 mmol) of 3-amino-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (see Step 1.6). Stirring in 7.5 ml of boiling ethanol and filtering while hot yield 4-(3-chloro-phenylamino)-3-([N-iso-butyloxycarbonyl-glycyl]-amino)-1H-pyrazolo[3,4-d]pyrimidine; HPLC: tRet(grad20-100/20)=12.8; FAB-MS: (M+H)+=418.

Provenance & Evidence