Dimethylformamide diethylacetal → HCID 21190642, compound

Participants

Reaction Steps

With the exclusion of moisture, 200 mg (0.767 mmol) of 3-amino-4-(3-chlorophenylamino)-1 H-pyrazolo[3,4-d]pyrimidine (see Step 1.6) are suspended in 3.2 ml of toluene; 150 μl (0.87 mmol) of N,N-dimethylformamide diethyl acetal in 6 ml of toluene are added and the reaction mixture is heated to boiling. After 5 hours, filtration is carried out, followed by thorough washing with toluene. 4-(3-Chloro-phenylamino)-3-(dimethylaminomethyleneamino)-1H-pyrazolo[3,4-d]pyrimidine is obtained; m.p. 243-245° C.; HPLC: tRet(grad20-100/20)=9.7; FAB-MS: (M+H)+=316.

Provenance & Evidence