Thiazole → HCID 10774002, compound

Participants

Reaction Steps

In a bomb tube, a mixture of 3.7 g (20 mmol) of 4-bromo-benzaldehyde, 6.64 ml (93 mmol) of thiazole, 2.94 g of potassium acetate and 1.16 g (1 mmol) of Pd(PPh3)4 is stirred in 50 ml of dimethylacetamide at 150° C. for 12 hours. The reaction mixture is concentrated by evaporation; water is added to the residue and the mixture is extracted three times with methylene chloride. The organic phases are filtered through cotton wadding, concentrated by evaporation and chromatographed (SiO2; hexane/ethyl acetate=1:2): 4-(Thiazol-5-yl)-benzaldehyde is obtained; HPLC:tRet(grad20-100/20)=11.4.

Provenance & Evidence