Acetic Acid → 4-(3-chloro-phenyl-amino)-3-(n-hexyl-amino)-1H-pyrazolo[3,4-d]pyrimidine

Participants

Reaction Steps

Analogously to Example 34, 261 mg (1.00 mmol) of 3-amino-4-(3-chlorophenylamino)-1H-pyrazolo[3,4-d]pyrimidine (see Step 1.6), 150 mg (1.5 mmol) of capronaidehyde and 180 mg of acetic acid are stirred in 39 ml of DMEU/methanol (1:2) and then reacted with 440 mg (7 mmol) of NaCNBH3. Stirring in DIPE yields 4-(3-chloro-phenyl-amino)-3-(n-hexyl-amino)-1H-pyrazolo[3,4-d]pyrimidine; HPLC: tRet(grad20-100)=9.9; FAB-MS: (M+H)+=345.

Provenance & Evidence