Acetic Acid → HCID 178514086, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 150 mg (0.391 mmol) of 3-(4-aminomethyl-phenylamino)-4-(3chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine hydrate (see Step 77.5), 95 mg (1.17 mmol) of potassium cyanate, 3 ml of ethanol, 3 ml of water and 0.0258 ml (0.451 mmol) of acetic acid is heated under reflux for 1 hour. After cooling to about 20° C., filtration and recrystallization of the filtration residue from methanol/water, 4-(3-chloro-phenylamino)-3-(4-{ureido-methyl}-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine is obtained; m.p. >280° C.; FAB-MS: (M+H)+=409.

Provenance & Evidence