Hydrochloric Acid → HCID 178462167, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 100 mg (0.177 mmol) of 3-[4-(N-{N-Boc-L-alanyl}-aminomethyl)-phenylamino]-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (see Example 85) and 4 ml of 3N methanolic hydrochloric acid is stirred at 20° C. for 15 hours and then about 5 ml of diethyl ether are added. Filtration and washing the filter residue with diethyl ether yield 4(3chloro-phenylamino)-3-[4-(N-{L-alanyl)-aminomethyl)-phenylamino]-1H-pyrazolo[3,4-d]-pyrimidine.1.9 hydrochloride having a water content of 6.36%; m.p. 220° C. (decomp.); ESI-MS: (M+H)+=437; [a]D20=−1.4=2.0° (c=0.508%, methanol).

Provenance & Evidence