Methanol → HCID 178482795, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg (1.34 mmol) of 3-(3aminomethyl-phenylamino)4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (water content: 1.79%), 402 mg (2.73 mmol) of N,N-dimethylformamide diethyl acetal and 5 ml of methanol is stirred at 30° C. for 2 hours and then concentrated by evaporation in vacuo. Crystallisation of the residue from ethyl acetate, filtration and washing the filter residue with ethyl acetate yield 4-(3-chloro-phenylamino)-3-[3-(dimethylamino-methyleneamino-methyl)-phenylamino]-1H-pyrazolo[3,4-d]pyrimidine having a water content of 1.68%; m.p. 175-177° C.; ESI-MS: (M+H)+=421.

Provenance & Evidence