HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bis(methylsulfanyl)methylidene)propanedinitrile → HCID 21190620, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bis(methylsulfanyl)methylidene)propanedinitrile | HCID 99229 | — |
| Reactant | tert-butyl N-((3-aminophenyl)methyl)carbamate | HCID 10775412 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21190620 | HCID 21190620 | — |
Reaction Steps
A mixture of 102.1 g (600 mmol) of 3,3-bis-methylmercapto-2-cyano-acrylonitrile, 133.3 g (600 mmol) of 3-(N-Boc-aminomethyl)-aniline (WO 93/00095) and 1100 ml of methanol is heated under reflux for 6.5 hours and then concentrated by evaporation in vacuo. Crystallization of the residue from ethyl acetate, filtration and washing the filtration residue with ethyl acetate yield 3-[3-(N-Boc-aminomethyl)-phenylamino]-2-cyano-3-methylmercapto-acrylonitrile; m.p. 150-151° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251911B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-6a22e000ac154f68b82b42ad47010123 |
| Source note | uspto-grants-2001_06 |