Diisopropylethylamine → HCID 178479422, compound

Participants

Reaction Steps

A mixture of 500 mg (1.303 mmol) of 3-(4-aminomethyl-phenylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine hydrate (see Step 77.5), 229 mg (1.562 mmol) of 1H-pyrazole-1-carbamidine monohydrochloride (Fluka), 202 mg (1.563 mmol) of N-ethyldiisopropylamine and 5 ml of DMF is stirred at RT for 7 hours and then concentrated by evaporation under a high vacuum. Crystallization of the residue from methanol, filtration and washing the filter residue with methanol yield 4-(3-chloro-phenyl-amino)-3-(4-{guanidino-methyl}-phenylamino)-1H-pyrazolo-[3,4-d]pyrimidine hydrochloride having a water content of 2.86%; m.p. 254-256° C.

Provenance & Evidence