Pyrazole-1-carboxamidine monohydrochloride → HCID 178512761, compound

Participants

Reaction Steps

A mixture of 200 mg (0.537 mmol) of 3-(3aminomethyl-phenylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (water content: 1.79%; see Step 90.5), 79 mg (0.539 mmol) of 1H-pyrazole-1-carbamidine monohydrochloride and 2 ml of DMF is stirred at RT for 65 hours and then concentrated by evaporation under a high vacuum. Crystallization of the residue from diethyl ether, filtration and washing the filter residue with diethyl ether yield 4-(3-chlorophenylamino)-3-(3-{guanidino-methyl}-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine.1.05 hydrochloride having a water content of 1.76%; m.p. 270° C. (decomp.).

Provenance & Evidence