2-(Bis(methylsulfanyl)methylidene)propanedinitrile → HCID 21190662, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 59.8 g (351.2 mmol) of 3,3bis-methylmercapto-2-cyano-acrylonitrile, 56.3 g (351.4 mmol) of N-Boc-ethylenediamine [for preparation see: J. Org. Chem. 60, 4305 (1995)] and 500 ml of ethyl acetate is stirred under reflux for 3 hours and then concentrated in vacuo to approximately half its original volume. The reaction mixture is cooled to 0° C.; 300 ml of diethyl ether are added and the mixture is stirred for a further 0.5 hour and filtered. After washing the filter residue with diethyl ether, 3-[2-(Boc-amino)-ethylamino]-2-cyano-3-methylmercapto-acrylonitrile is obtained; m.p. 123-125° C.

Provenance & Evidence