4-Methylmorpholine → HCID 10158801, compound

Participants

Reaction Steps

Isobutyl chloroformate (0.625 g, 4.58 mmol) and N-methylmorpholine (0.506 g, 5.00 mmol) were added to an ice cold solution of 0.542 g (4.58 mmol) of 4-chloro-but-2-yanoic acid in 7mL of tetrahydrofuran under nitrogen. After stirring for 30min, a solution of 0.72 g (2.287 mmol) of N-(3-bromophenyl)-4,6-quinazolindiamine in 3.35 mL of pyridine was added and the mixture was stirred at 0° C. for 1 h. The reaction was quenched with ice water. The product was collected by filtration, washed with water and ether, and dried in vacuo to give 0.537 g of brown solid; ESMS m/z 417.0 (M+H+).

Provenance & Evidence