Dimethylamine → HCID 10274823, compound

HRID 1069000Notes

Reaction equation

HRID 1069000 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20]4[C:21](=O)[C:22](=[O:27])[C:23]=4[O:24]CC)[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:29][NH:30][CH3:31]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20]4[C:23](=[O:24])[C:22](=[O:27])[C:21]=4[N:30]([CH3:31])[CH3:29])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 10160368HCID 10160368, compound

Product 1

HCID 10274823HCID 10274823, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.8 g of 3-[4-(3-Bromo-phenylamino)-quinazolin-6-ylamino]4-ethoxy-cyclobut-3-ene-1,2-dione, 8 mL of 40% dimethylamine, and 8 mL of ethanol was refluxed for 2 hr. The mixture was cooled to room temperature and the solid was collected and washed with ethanol and ether giving 0.7 g of 3-[4-(3-Bromo-phenylamino)-quinazolin-6-ylamino]-4-dimethylamino-cyclobut-3-ene-1,2-dione as a yellow powder: mass spectrum (m/e): M+H 438.1, 440.1.

Workup

  1. temperaturewas refluxed for 2 hr
  2. customthe solid was collected
  3. washwashed with ethanol and ether giving 0.7 g of 3-[4-(3-Bromo-phenylamino)-quinazolin-6-ylamino]-4-dimethylamino-cyclobut-3-ene-1,2-dione as a yellow powder

Sources & evidence

ORD record
ord-59ba2a3d84f74b16913a0a76dcf34367
Source dataset
uspto-grants-2001_06
Patent number
US06251912B1

Reaction notes

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