Methyl iodide → HCID 77750436, compound

Participants

Reaction Steps

Sodium hydride (65.3 mg) was added to a solution of the diol from step (b) (1.23 g) and methyl iodide (0.13 ml) in DMF (4 ml) and the mixture was stirred for 4 h. Ammonium chloride solution was added and the mixture was extracted with ethyl acetate. The organic extracts were dried, concentrated and purified (SiO2, petrol:acetone 4:1 and petrol:ethyl acetate 2:1 as eluants) to give the subtitle compound (676 mg) as a 1:2.5 mixture with the regioisomeric [1R-[1α,2α,3β,5β(1R*,2S*)]]-3-[7-[N-(2,4-dimethoxyphenylmethyl)-(2-phenylcyclopropyl)amino]]-5-propylthio-3H-1,2,3-triazolo[4,5d]pyrimidin-3-yl]-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-methoxycyclopentanol compound.

Provenance & Evidence