Acetyl chloride → Methyl 3-bromo-4-methylbenzoate

HRID 1069063Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].[C:12](Cl)(=O)C>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([O:7][CH3:12])=[O:6]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 821303-Bromo-4-methylbenzoic acid

Product 1

HCID 7015747Methyl 3-bromo-4-methylbenzoate

Procedure

n.m.r. δ values include 2.40 (s, 3 H), 3.90 (s, 3 H), 7.25 (d, 1 H), 7.80 (d, 1 H), 8.15 (s, 1 H), from 3-bromo4-methylbenzoic acid (2.63 g) and acetyl chloride(1.8 mL).

Sources & evidence

ORD record: ord-466f08d24faf45e3832818aeb1253b5d
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06251925B1

Reaction notes

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