Methyl 3-(3-nitrophenyl)benzoate → (1,1'-Biphenyl)-3-carboxylic acid, 3'-amino-, methyl ester

참여 물질

반응 단계

To a stirred solution of 3′-nitro-[1,1′-biphenyl]-3-carboxylic acid methyl ester (4.47 g) in anhydrous tetrahydrofuran (125 mL) under a blanket of nitrogen was added 10% palladium on activated charcoal (860 mg). The reaction was evacuated and placed under a hydrogen atmosphere and stirred overnight. The reaction mixture was filtered through Celite and the solvent was removed under reduced pressure to yield a gray oil (4.4 g). The residue was chromatographed on silica eluting with 3:1 hexane:ethyl acetate. Concentration of the appropriate fractions provided the title compound as a white solid (3.5 g).

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