(R)-(+)-3-Chlorostyrene oxide → HCID 54219870, compound

Participants

Reaction Steps

A solution of methyl-3′-[(2-amino)ethoxy]-[1,1′-biphenyl]-3-carboxylate (284.5 mg) and (R)-(-)-3-chlorostyrene oxide (124 mg) in nitromethane (4.0 mL) was heated at 70-75° C. for 20 h. The mixture was concentrated with a rotary evaporator to afford the crude product. Purification by silica gel chromatography (eluting with ethyl acetate followed by 10:1 ethyl acetate: methanol followed by 3:1 ethyl acetate: methanol) afforded the title compound (190.6 mg) as a colorless oil.

Provenance & Evidence