HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 53637572, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | HCID 54549146 | HCID 54549146 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 53637572 | HCID 53637572 | 96.6% |
Reaction Steps
A solution of methyl (R)-2-(3,5-dichlorophenyl)-2-hydroxyethanoate (10.485 g), tert-butyidimethylsilyl chloride (8.07 g), and imidazole (3.64 g) in N,N-dimethylformamide (50 mL) was stirred under nitrogen for 18 h. Volatiles were then removed under vacuum and the residue was chromatographed on silica gel, eluting with hexanelethyl acetate (20:1) The title compound was obtained as a colorless oil (15.05 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251925B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-3c31d468a27041fb833f68fbf895b491 |
| Source note | uspto-grants-2001_06 |