HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-[(tert-butoxycarbonyl)-[2-(tertbutyidimethylsilanyloxy)-2-(3-chlorophenyl)ethyl]amino}acetaldehyde → (R)-5-[3-[[2-[[2-(3-Chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]phenyl]-2,3-dihydro-7-benzofurancarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-[(tert-butoxycarbonyl)-[2-(tertbutyidimethylsilanyloxy)-2-(3-chlorophenyl)ethyl]amino}acetaldehyde | HCID 20666899 | — |
| Reactant | 5-(3-Aminophenyl)-2,3-dihydro-7-benzofurancarboxylic acid methyl ester | HCID 69779689 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | (R)-5-[3-[[2-[[2-(3-Chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]phenyl]-2,3-dihydro-7-benzofurancarboxylic acid methyl ester | HCID 69779821 | — |
Reaction Steps
TLC Rf (4:1 hexane/ethyl acetate)=0.14; from 5-(3-aminophenyl)-2,3-dihydro-7-benzofurancarboxylic acid methyl ester (500 mg) and (R)-[(tert-butoxycarbonyl)-[2-(tert-butyldimethylsilanoxy)-2-(3-chlorophenyl)ethyl]amino]-acetaldehyde (1.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251925B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-39e2169e80134b91a47e501a15eaa194 |
| Source note | uspto-grants-2001_06 |