Lithium hydroxide, monohydrate → (R)-3'-[[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Lithium hydroxide, monohydrate	HCID 168937	—
Reactant	(R)-3'-[[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid dimethyl ester dihydrochloride	HCID 69780650	—
Product	(R)-3'-[[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid	HCID 9955618	—

Reaction Steps

n.m.r. (CD3OD) δ values include 2.97-3.00 (m,1 H), 3.43-3.45 (m, 2 H), 4.97 (dd, 1 H), 6.69 (d, 1 H), 6.97-6.99 (m, 2 H), 7.20-7.31 (m, 4 H), 7.42 (s, 1 H), 7.73 (d, 1 H), 8.19 (d, 1 H), 8.37 (s, 1 H); from (R)-3′-[[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1′-biphenyl]-3,4-dicarboxylic acid dimethyl ester dihydrochloride (500 mg), and lithium hydroxide monohydrate (303 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06251925B1
Source dataset	uspto-grants-2001_06
ORD ID	ord-8f3698c01efb4b8f8e8a21888a818169
Source note	uspto-grants-2001_06