HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 11661536, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Oxolane--water (1/1) | HCID 21881883 | — |
| Reactant | HCID 69779815 | HCID 69779815 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 11661536 | HCID 11661536 | — |
Reaction Steps
n.m.r. (CD3OD) δ values include 3.11-3.29 (m, 1 H), 3.58 (t, 2 H), 4.97 (dd, 1 H), 6.76 (d, 1 H), 6.97 (s, 1 H), 6.99 (d, 1 H), 7.26-7.35 (m, 4 H), 7.46 (s, 1 H), 8.51 (s, 1 H), 8.76 (s, 1 H), 9.00 (s, 1 H); from (R)-5-[3-[[2-[[2-(3-chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]phenyl]-3-pyridinecarboxylic acid methyl ester (251 mg), 4 N hydrochloric acid in 1,4-dioxane (10 mL) and lithium hydroxide monohydrate (96 mg) in 3:1 tetrahydrofuran-water (20 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251925B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-79854a7493d7496aabbef6dea60d8a19 |
| Source note | uspto-grants-2001_06 |